Diablo 2 Resurrected's punishing -100% all resistance in Hell mode will stop you from attacking unless you have the right gear or a very useful rune word, as long as you are strong enough to explore the boundaries of hell.

Powerful runes are always hard to come by, but not impossible, and many of them are actually endgame items. The most popular Diablo 2 Resurrected Ladder Items For Sale of these rune words are Enigma, which makes Teleport available to any character, Infinity, which greatly reduces enemy resistance, and Call to Arms, which grants the Barbarian Warcry skill.

Enigma (Body Armors) - Jah + Ith + Ber

+2 to all skills, chance to find magic items, damage reduction, and strength attributes - items are pretty good on their own, Enigma's most common items are Mage's Plate, Shroud of Dusk, and Archon's Plate, as long as their mana allows, which can be used by any class character, and as such, is considered the best rune word item.

Grief (Swords, Axes) - Eth + Tir + Lo + Mal + Ral

Grief increases the damage of the weapon to 400, the attack speed to 40%, and ignores the target's defense, so it is considered one of the best weapons for melee characters.

Base items vary by role. Barbarians mainly use Zweihanders, Colossus Blades or Berserker Axes. Retribution Paladins mainly use Phase Blades with fast attack speed.

Last Wish (Sword, Axe, Hammer) - Jah + Mal + Jah + Sur + Jah + Ber

Last Wish requires three Jah runes, which are hard to come by, but it's a bit of a "meh" choice compared to the runes' worth. Among the guaranteed options, Smash, Life Diversion, Fade, and Ignore Target Defense are all good, but the damage is low and there is no attack speed option. Additionally, the power aura overlaps with the act 2 mercenaries.

Therefore, Last Wish is mainly used by Smite Paladins. Retribution is unaffected by weapon damage and critical strike options, and auras are easy to manage - so Retribution Paladins are the best class to clear Pandemonium events. Last Wish is mainly used in Phase Blade.

Infinity (Polearms) - Ber + Mal + Ber + Ist

Equipping Infinite grants a level 12 Aura of Faith, reducing surrounding enemies' defense by 83% and resistance by 85%. In addition to that, it also prevents monster recovery, HP level, and smashing blows. It is mainly used for sorceress or necromancer mercenaries who need to deal with hell monster resistance. The most commonly used base items are the Giant Thresher, Mystic Axe, and Long Axe.

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